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KMID : 0357919800140040044
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Korean Journal of Pathology
1980 Volume.14 No. 4 p.44 ~ p.50
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Carcinoma Arising in Pleomorphic Adenoma of Salivary Gland -Report of 4 cases
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Abstract
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The terms "malignant mixed tumor" and "carcinoma arising in pleomorphic adenoma"
have been used interchangeably. However, they are theoretically quite different. The
term carcinoma arising in pleomorphic adenoma refers to an epithelial malignancy in
which remnants of benign pleomorphic adenoma (mixed tumor) matrix can be identified.
And metastasis contains only the carcinomatous component. The important microscopic
findings are 1) destructive infiltrative growth 2) necrosis and extensive hyalinization 3)
frequent mitosis and pleomorphism 4) dystrophic calcification 5) anigo and perineural
invasion, and 6) metastasis.
Recently we have experienced four cases of major salivary gland carcinomas that
showed residual foci of benign pleomorphic adenoma. Detailed histological examination
confirmed that these tumors fit the criteria of "carcinoma arising in pleomorphic
adenoma".
The tumors occurred most commonly in parotid(3 cases) , in males(3 cases) and over
the age of 60 years(4 cases). The malignant part of the tumors was comprised of poorly
differentiated adenocarcinoma in three, and squamous cell carcinoma in one case. One
patient died of brain metastasis.
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